4/14/2023 0 Comments Eye with no pupilSome individuals may not have symptoms associated with the affected pupil. When no longer focusing on the close at hand object, the affected pupil may remain smaller than normal or grow larger (re-dilate) at an abnormally slow rate, sometimes taking as long as several minutes to return to its original (i.e. Eventually, after months or years, the pupil, which was initially larger than the unaffected pupil, will become smaller than the unaffected pupil. This reminds of the movement of an earthworm. If the pupil is observed with a loupe or microscope a typical behavior can be observed both spontaneously or during near response: Some sectors of the sphincter muscles constrict and others don’t. The pupil will constrict slowly when focusing (=accommodating) on objects close at hand (normally referred to as near response). In many cases it is not ideally round but slightly ovally distorted. In most patients with Adie syndrome the affected pupil is larger than normal (dilated) all the time and does not constrict very much or not at all in response to direct light. The pupil normally opens wider (dilates) in dim light or darkness, when focusing on far away objects, or when a person is excited. Normally the pupil gets smaller (constricts) in the presence of light or when focusing on nearby objects. When a person’s pupils are of unequal size, the term anisocoria may be used. When only abnormalities affecting the pupil are present, the disorder may be referred to as Adie’s pupil, Adie’s tonic pupil or, most commonly, tonic pupil. However, these findings may not develop at the same time. The term Adie syndrome is used when both abnormalities of the pupil and loss of deep tendon reflexes are present. Adie syndrome involves a usually non progressive and limited damage to the autonomic nervous system, which is the portion of the nervous system that controls or regulates certain involuntary body functions including the reaction of the pupils to stimuli. In rare cases localized disturbance of sweat secretion is associated with Adie syndrome (Ross syndrome). In most individuals, the cause is unknown (idiopathic), but Adie syndrome can occur as due to other conditions such as trauma, surgery, lack of blood flow (ischemia) or infection. Absent or poor tendon reflexes are also associated with this disorder. In most patients the pupil is larger than normal (dilated) and slow to react in response to direct light.
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